Approaching Oncology From Multiple Fronts
RATIONAL DRUG DESIGN
Rational drug design is a focused strategy for drug development that is grounded on a solid foundation in the basic sciences, driven by the rigor of laboratory research, and proven clinically.
DRUG DISCOVERY TECHNOLOGY
Novartis Oncology targets are selected based on extensive research to understand the molecular structure of drug receptors, the specific biochemical characteristics of intracellular proteins, the unique products of aberrant genes, and the cellular processes underlying the etiology of cancer.
State-of-the-art technology is used to identify the best compounds to hit specific molecular targets accurately, and effectively. When a natural compound is not readily found, synthetic molecules that mimic the natural ligands of receptors can be engineered from the understanding of the underlying mechanisms gleaned from previous research.
Working from the roadmap of life—the human genome—researchers have gained an understanding of the complete genetic make-up of human cells, which has provided a new resource for current drug design. The challenge of functional genomic is to understand the function of each gene and its interaction with each of the nearly 30,000 others in the genome.
Tools are now available to facilitate microexperiments that can answer complex questions about each gene in the genome simultaneously. For example, a single experiment can identify the genes that are expressed at high levels in lung tumors, but not in healthy lung tissues.
This type of research can be used to identify molecular targets and compounds, to genetically profile tumors or patients, and in the future, to guide and customize therapeutic choices.
Novartis Oncology uses the lessons learned in the laboratory to deliver clinical benefits. Additionally, observations made in clinical settings help to refocus or innovate basic research hypotheses. Active basic and clinical research programs ensure that optimal cancer treatments will be developed.
Novartis Oncology Collaborations
Our people are the key to successful collaborations. Novartis Oncology has formed strong relationships with several leading companies, industry, and academic institutions to support research for discovering, developing, and producing broadly available novel therapies that improve the lives of cancer patients.
ABOUT NOVARTIS ONCOLOGY
We are one of the premier companies providing you with the best oncology treatments available.